| Time | Status | Match | FT | H1 | Stats |
| 20/11/2021 14:00 |
(FT) | Mosta[9] Gzira United[8] |
2 2 |
1 2 |
MF | ME |
| 20/11/2021 16:00 |
(FT) | Sliema Wanderers FC[12] Valletta FC[4] |
0 3 |
0 1 |
MF | ME |
| 20/11/2021 18:00 |
(FT) | Gudja United[10] Floriana[3] |
0 1 |
0 0 |
MF | ME |
| 21/11/2021 11:30 |
(FT) | Santa Lucia[11] Birkirkara FC[2] |
2 0 |
2 0 |
MF | ME |
| 21/11/2021 14:00 |
(FT) | Sirens[7] Balzan[6] |
1 6 |
0 5 |
MF | ME |
| 21/11/2021 18:00 |
(FT) | Hibernians FC[1] Hamrun Spartans[5] |
1 0 |
1 0 |
MF | ME |