| Time | Status | Match | FT | H1 | Stats |
| 18/09/2021 17:00 |
(FT) | Santa Lucia[6] Sirens[5] |
1 3 |
0 1 |
MF | ME |
| 18/09/2021 19:00 |
(FT) | Valletta FC[3] Gzira United[10] |
0 2 |
0 1 |
MF | ME |
| 18/09/2021 21:00 |
(FT) | Hibernians FC[1] Mosta[12] |
3 2 |
1 0 |
MF | ME |
| 19/09/2021 17:00 |
(FT) | Birkirkara FC[2] Floriana[4] |
1 1 |
0 1 |
MF | ME |
| 19/09/2021 19:00 |
(FT) | Sliema Wanderers FC[9] Gudja United[11] |
2 3 |
2 1 |
MF | ME |
| 19/09/2021 21:00 |
(FT) | Hamrun Spartans[7] Balzan[8] |
0 1 |
0 1 |
MF | ME |