| Time | Status | Match | FT | H1 | Stats |
| 30/10/2021 15:00 |
(FT) | Birkirkara FC[2] Hibernians FC[1] |
1 1 |
1 0 |
MF | ME |
| 30/10/2021 17:00 |
(FT) | Valletta FC[5] Santa Lucia[10] |
5 3 |
3 1 |
MF | ME |
| 30/10/2021 19:00 |
(FT) | Hamrun Spartans[6] Sirens[3] |
1 0 |
0 0 |
MF | ME |
| 31/10/2021 15:00 |
(FT) | Balzan[8] Gudja United[9] |
1 0 |
1 0 |
MF | ME |
| 31/10/2021 16:59 |
(FT) | Floriana[4] Gzira United[7] |
2 1 |
0 1 |
MF | ME |
| 31/10/2021 19:00 |
(FT) | Sliema Wanderers FC[12] Mosta[11] |
2 3 |
0 1 |
MF | ME |