| Time | Status | Match | FT | H1 | Stats |
| 17/01/2022 19:00 |
(FT) | Valletta FC[8] Floriana[2] |
0 2 |
0 1 |
MF | ME |
| 17/01/2022 19:00 |
(FT) | Hamrun Spartans[3] Mosta[11] |
2 1 |
1 1 |
MF | ME |
| 18/01/2022 16:59 |
(FT) | Sliema Wanderers FC[12] Gzira United[7] |
1 3 |
0 2 |
MF | ME |
| 18/01/2022 19:00 |
(FT) | Hibernians FC[1] Sirens[6] |
1 1 |
1 0 |
MF | ME |
| 19/01/2022 16:59 |
(FT) | Santa Lucia[10] Gudja United[9] |
0 3 |
0 1 |
MF | ME |
| 19/01/2022 21:00 |
(FT) | Birkirkara FC[4] Balzan[5] |
3 2 |
0 2 |
MF | ME |