| Time | Status | Match | FT | H1 | Stats |
| 11/09/2021 17:00 |
(FT) | Mosta[10] Hamrun Spartans[11] |
1 2 |
1 1 |
MF | ME |
| 11/09/2021 19:00 |
(FT) | Floriana[7] Valletta FC[3] |
3 0 |
1 0 |
MF | ME |
| 11/09/2021 21:00 |
(FT) | Gzira United[9] Sliema Wanderers FC[8] |
1 1 |
1 0 |
MF | ME |
| 12/09/2021 17:00 |
(FT) | Sirens[4] Hibernians FC[2] |
1 3 |
0 2 |
MF | ME |
| 12/09/2021 19:00 |
(FT) | Balzan[5] Birkirkara FC[1] |
1 2 |
1 2 |
MF | ME |
| 12/09/2021 21:00 |
(FT) | Gudja United[12] Santa Lucia[6] |
2 2 |
1 1 |
MF | ME |