| Time | Status | Match | FT | H1 | Stats |
| 23/10/2021 15:00 |
(FT) | Gudja United[7] Hamrun Spartans[8] |
1 3 |
0 1 |
MF | ME |
| 23/10/2021 19:00 |
(FT) | Mosta[11] Floriana[3] |
1 1 |
0 1 |
MF | ME |
| 23/10/2021 20:00 |
(FT) | Gzira United[4] Balzan[9] |
1 2 |
0 0 |
MF | ME |
| 24/10/2021 15:00 |
(FT) | Santa Lucia[10] Sliema Wanderers FC[12] |
0 0 |
0 0 |
MF | ME |
| 24/10/2021 17:00 |
(FT) | Hibernians FC[1] Valletta FC[5] |
1 1 |
1 0 |
MF | ME |
| 24/10/2021 19:00 |
(FT) | Sirens[6] Birkirkara FC[2] |
3 2 |
0 2 |
MF | ME |