| Time | Status | Match | FT | H1 | Stats |
| 01/10/2021 20:00 |
(FT) | Groningen[16] Twente Enschede[6] |
1 1 |
1 0 |
MF | ME |
| 02/10/2021 18:45 |
(FT) | RKC Waalwijk[15] Go Ahead Eagles[14] |
1 1 |
0 1 |
MF | ME |
| 02/10/2021 20:00 |
(FT) | Heracles Almelo[11] Willem II[2] |
3 2 |
1 0 |
MF | ME |
| 02/10/2021 20:00 |
(FT) | Zwolle[18] SC Heerenveen[8] |
0 1 |
0 0 |
MF | ME |
| 02/10/2021 21:00 |
(FT) | Fortuna Sittard[17] NEC Nijmegen[10] |
1 3 |
1 2 |
MF | ME |
| 03/10/2021 14:30 |
(FT) | Cambuur Leeuwarden[7] AZ Alkmaar[12] |
1 3 |
0 2 |
MF | ME |
| 03/10/2021 14:30 |
(FT) | Ajax Amsterdam[1] Utrecht[5] |
0 1 |
0 0 |
MF | ME |
| 03/10/2021 16:45 |
(FT) | Vitesse Arnhem[9] Feyenoord Rotterdam[3] |
2 1 |
1 1 |
MF | ME |
| 03/10/2021 20:00 |
(FT) | PSV Eindhoven[4] Sparta Rotterdam[13] |
2 1 |
0 0 |
MF | ME |