| Time | Status | Match | FT | H1 | Stats |
| 26/11/2021 20:00 |
(FT) | NEC Nijmegen[8] Cambuur Leeuwarden[7] |
2 3 |
2 1 |
MF | ME |
| 27/11/2021 18:45 |
(FT) | Fortuna Sittard[17] Groningen[14] |
1 4 |
1 2 |
MF | ME |
| 27/11/2021 20:00 |
(FT) | Zwolle[18] RKC Waalwijk[15] |
0 0 |
0 0 |
MF | ME |
| 27/11/2021 21:00 |
(FT) | Willem II[9] Go Ahead Eagles[11] |
0 1 |
0 0 |
MF | ME |
| 28/11/2021 12:15 |
(FT) | Sparta Rotterdam[16] Ajax Amsterdam[1] |
0 1 |
0 1 |
MF | ME |
| 28/11/2021 14:30 |
(FT) | Twente Enschede[6] Feyenoord Rotterdam[3] |
0 0 |
0 0 |
MF | ME |
| 28/11/2021 14:30 |
(FT) | Utrecht[4] Heracles Almelo[13] |
1 0 |
0 0 |
MF | ME |
| 28/11/2021 16:45 |
(FT) | SC Heerenveen[10] PSV Eindhoven[2] |
1 1 |
0 1 |
MF | ME |
| 28/11/2021 20:00 |
(FT) | Vitesse Arnhem[5] AZ Alkmaar[12] |
0 0 |
0 0 |
MF | ME |