| Time | Status | Match | FT | H1 | Stats |
| 27/08/2021 20:00 |
(FT) | Fortuna Sittard[7] RKC Waalwijk[8] |
2 2 |
1 1 |
MF | ME |
| 28/08/2021 18:45 |
(FT) | Cambuur Leeuwarden[18] Twente Enschede[12] |
2 0 |
0 0 |
MF | ME |
| 28/08/2021 20:00 |
(FT) | Go Ahead Eagles[16] Sparta Rotterdam[14] |
2 0 |
1 0 |
MF | ME |
| 28/08/2021 20:00 |
(FT) | PSV Eindhoven[2] Groningen[6] |
5 2 |
3 2 |
MF | ME |
| 28/08/2021 21:00 |
(FT) | Willem II[9] Zwolle[17] |
1 0 |
0 0 |
MF | ME |
| 29/08/2021 12:15 |
(FT) | Utrecht[5] Feyenoord Rotterdam[1] |
3 1 |
1 1 |
MF | ME |
| 29/08/2021 14:30 |
(FT) | Heracles Almelo[13] NEC Nijmegen[11] |
0 1 |
0 0 |
MF | ME |
| 29/08/2021 14:30 |
(FT) | Ajax Amsterdam[4] Vitesse Arnhem[10] |
5 0 |
3 0 |
MF | ME |
| 29/08/2021 16:45 |
(FT) | SC Heerenveen[3] AZ Alkmaar[15] |
1 3 |
1 1 |
MF | ME |