| Time | Status | Match | FT | H1 | Stats |
| 18/12/2021 16:30 |
(FT) | Fortuna Sittard[16] Utrecht[6] |
2 2 |
1 1 |
MF | ME |
| 18/12/2021 18:45 |
(FT) | Sparta Rotterdam[17] Vitesse Arnhem[4] |
2 2 |
0 2 |
MF | ME |
| 18/12/2021 20:00 |
(FT) | AZ Alkmaar[8] Willem II[13] |
4 1 |
1 1 |
MF | ME |
| 18/12/2021 20:00 |
(FT) | Heracles Almelo[15] Groningen[11] |
4 2 |
2 1 |
MF | ME |
| 18/12/2021 21:00 |
(FT) | Zwolle[18] Twente Enschede[5] |
1 3 |
0 2 |
MF | ME |
| 19/12/2021 12:15 |
(FT) | Cambuur Leeuwarden[7] SC Heerenveen[9] |
1 2 |
1 1 |
MF | ME |
| 19/12/2021 14:30 |
(FT) | Go Ahead Eagles[10] NEC Nijmegen[12] |
0 2 |
0 2 |
MF | ME |
| 19/12/2021 14:30 |
(FT) | Feyenoord Rotterdam[3] Ajax Amsterdam[2] |
0 2 |
0 1 |
MF | ME |
| 19/12/2021 16:45 |
(FT) | RKC Waalwijk[14] PSV Eindhoven[1] |
1 4 |
0 1 |
MF | ME |