| Time | Status | Match | FT | H1 | Stats |
| 17/09/2021 20:45 |
(FT) | Cercle Brugge[13] AS Eupen[6] |
1 2 |
1 1 |
MF | ME |
| 18/09/2021 16:15 |
(FT) | Oostende[11] Beerschot AC[18] |
3 1 |
2 0 |
MF | ME |
| 18/09/2021 18:30 |
(FT) | St Gilloise[2] Zulte-Waregem[14] |
2 1 |
0 0 |
MF | ME |
| 18/09/2021 18:30 |
(FT) | KV Mechelen[17] Oud Heverlee[16] |
2 0 |
2 0 |
MF | ME |
| 18/09/2021 20:45 |
(FT) | Sporting Charleroi[3] Club Brugge[1] |
0 1 |
0 0 |
MF | ME |
| 19/09/2021 13:30 |
(FT) | St-Truidense VV[9] Genk[5] |
1 2 |
1 0 |
MF | ME |
| 19/09/2021 16:00 |
(FT) | Royal Antwerp[12] Seraing United[10] |
2 1 |
0 0 |
MF | ME |
| 19/09/2021 18:30 |
(FT) | Standard Liege[4] Anderlecht[7] |
0 1 |
0 1 |
MF | ME |
| 19/09/2021 21:00 |
(FT) | Kortrijk[8] Gent[15] |
1 0 |
1 0 |
MF | ME |