| Time | Status | Match | FT | H1 | Stats |
| 21/01/2022 20:45 |
(FT) | Oostende[16] Royal Antwerp[3] |
1 2 |
0 0 |
MF | ME |
| 22/01/2022 16:15 |
(FT) | Kortrijk[9] AS Eupen[12] |
1 1 |
0 1 |
MF | ME |
| 22/01/2022 18:30 |
(FT) | St-Truidense VV[13] Seraing United[17] |
3 1 |
1 1 |
MF | ME |
| 22/01/2022 18:30 |
(FT) | Beerschot AC[18] Oud Heverlee[11] |
3 1 |
2 1 |
MF | ME |
| 22/01/2022 20:45 |
(FT) | Sporting Charleroi[6] Gent[5] |
0 0 |
0 0 |
MF | ME |
| 23/01/2022 13:30 |
(FT) | Standard Liege[14] Club Brugge[2] |
2 2 |
1 1 |
MF | ME |
| 23/01/2022 16:00 |
(FT) | St Gilloise[1] Genk[8] |
2 1 |
1 0 |
MF | ME |
| 23/01/2022 18:30 |
(FT) | KV Mechelen[7] Anderlecht[4] |
0 1 |
0 1 |
MF | ME |
| 23/01/2022 21:00 |
(FT) | Cercle Brugge[10] Zulte-Waregem[15] |
3 1 |
2 0 |
MF | ME |