| Time | Status | Match | FT | H1 | Stats |
| 22/10/2021 20:45 |
(FT) | Seraing United[14] Sporting Charleroi[7] |
1 3 |
0 2 |
MF | ME |
| 23/10/2021 16:15 |
(FT) | Cercle Brugge[17] Standard Liege[13] |
1 1 |
1 1 |
MF | ME |
| 23/10/2021 18:30 |
(FT) | Kortrijk[10] Oostende[9] |
1 0 |
1 0 |
MF | ME |
| 23/10/2021 18:30 |
(FT) | KV Mechelen[5] Zulte-Waregem[15] |
2 2 |
2 2 |
MF | ME |
| 23/10/2021 20:45 |
(FT) | AS Eupen[3] St Gilloise[1] |
2 3 |
0 2 |
MF | ME |
| 24/10/2021 13:30 |
(FT) | Royal Antwerp[4] Club Brugge[2] |
1 1 |
1 1 |
MF | ME |
| 24/10/2021 16:00 |
(FT) | Anderlecht[6] Beerschot AC[18] |
4 2 |
1 0 |
MF | ME |
| 24/10/2021 18:30 |
(FT) | Genk[8] Gent[12] |
0 3 |
0 1 |
MF | ME |
| 24/10/2021 21:00 |
(FT) | Oud Heverlee[16] St-Truidense VV[11] |
4 1 |
0 0 |
MF | ME |