| Time | Status | Match | FT | H1 | Stats |
| 26/11/2021 20:45 |
(FT) | St Gilloise[1] Oud Heverlee[13] |
1 3 |
0 2 |
MF | ME |
| 27/11/2021 16:15 |
(FT) | Seraing United[15] St-Truidense VV[11] |
2 0 |
1 0 |
MF | ME |
| 27/11/2021 18:30 |
(FT) | AS Eupen[9] Kortrijk[10] |
2 2 |
2 1 |
MF | ME |
| 27/11/2021 18:30 |
(FT) | Cercle Brugge[17] KV Mechelen[5] |
3 1 |
1 1 |
MF | ME |
| 27/11/2021 20:45 |
(FT) | Sporting Charleroi[4] Anderlecht[6] |
1 3 |
0 1 |
MF | ME |
| 28/11/2021 13:30 |
(FT) | Genk[8] Club Brugge[3] |
2 3 |
0 1 |
MF | ME |
| 28/11/2021 16:00 |
(FT) | Zulte-Waregem[16] Beerschot AC[18] |
2 0 |
2 0 |
MF | ME |
| 28/11/2021 18:30 |
(FT) | Gent[7] Standard Liege[12] |
3 1 |
1 0 |
MF | ME |
| 28/11/2021 21:00 |
(FT) | Royal Antwerp[2] Oostende[14] |
3 0 |
0 0 |
MF | ME |