| Time | Status | Match | FT | H1 | Stats |
| 29/10/2021 21:00 |
(FT) | Oostende[11] KV Mechelen[7] |
2 4 |
0 2 |
MF | ME |
| 30/10/2021 16:15 |
(FT) | Sporting Charleroi[5] AS Eupen[6] |
3 0 |
0 0 |
MF | ME |
| 30/10/2021 18:30 |
(FT) | Beerschot AC[18] Seraing United[16] |
3 0 |
1 0 |
MF | ME |
| 30/10/2021 18:30 |
(FT) | Standard Liege[13] Kortrijk[8] |
1 1 |
0 0 |
MF | ME |
| 30/10/2021 20:45 |
(FT) | St-Truidense VV[12] Club Brugge[2] |
1 2 |
1 1 |
MF | ME |
| 31/10/2021 13:30 |
(FT) | Zulte-Waregem[15] Genk[10] |
2 6 |
0 2 |
MF | ME |
| 31/10/2021 16:00 |
(FT) | Cercle Brugge[17] Royal Antwerp[3] |
0 1 |
0 0 |
MF | ME |
| 31/10/2021 18:30 |
(FT) | Anderlecht[4] Oud Heverlee[14] |
2 2 |
1 2 |
MF | ME |
| 31/10/2021 21:00 |
(FT) | Gent[9] St Gilloise[1] |
0 2 |
0 2 |
MF | ME |