| Time | Status | Match | FT | H1 | Stats | |
| 20/04/2022 01:00 |
(FT) | Cincinnati[MLS-11] Pittsburgh Riverhounds[USL CH-4] |
0 0 |
0 0 |
MF | ME | |
| 90 phút [0-0], 120 phút [2-0], Cincinnati thắng | ||||||
| 20/04/2022 01:00 |
(FT) | Miami[USL CH-13] Inter Miami[MLS-14] |
0 1 |
0 0 |
MF | ME | |
| 20/04/2022 01:30 |
(FT) | Detroit City[USL CH-6] Columbus Crew[MLS-7] |
2 1 |
0 1 |
MF | ME | |
| 20/04/2022 02:30 |
(FT) | Houston Dynamo[MLS-6] Rio Grande Valley Fc Toros[USL CH-16] |
2 1 |
1 0 |
MF | ME | |
| 20/04/2022 04:30 |
(FT) | San Jose Earthquakes[MLS-14] Bay Cities |
5 0 |
2 0 |
MF | ME | |
| 20/04/2022 04:30 |
(FT) | Los Angeles Galaxy[MLS-2] San Diego Loyal Sc[USL CH-1] |
1 0 |
1 0 |
MF | ME | |
| 21/04/2022 00:00 |
(FT) | Rochester Rhinos Motown |
2 2 |
2 1 |
MF | ME | |
| 90 phút [2-2], 120 phút [2-2], Penalty [4-3], Rochester Rhinos thắng | ||||||
| 21/04/2022 00:30 |
(FT) | Richmond Kickers North Carolina Fusion U23 |
0 0 |
0 0 |
MF | ME | |
| 90 phút [0-0], 120 phút [1-0], Richmond Kickers thắng | ||||||
| 21/04/2022 01:00 |
(FT) | Hartford Athletic[USL CH-27] New York Red Bulls[MLS-3] |
1 2 |
0 2 |
MF | ME | |
| 21/04/2022 01:00 |
(FT) | Greenville Triumph Charlotte Eagles[MLS-8] |
1 1 |
0 1 |
MF | ME | |
| 90 phút [1-1], 120 phút [1-2], Charlotte Eagles thắng | ||||||
| 21/04/2022 01:00 |
(FT) | Forward Madison Minnesota United[MLS-7] |
0 2 |
0 0 |
MF | ME | |
| 21/04/2022 01:00 |
(FT) | Orlando City[MLS-2] Tampa Bay Rowdies[USL CH-6] |
2 1 |
0 0 |
MF | ME | |
| 21/04/2022 01:30 |
(FT) | Louisville City[USL CH-1] Saint Louis City B |
0 0 |
0 0 |
MF | ME | |
| 90 phút [0-0], 120 phút [0-0], Penalty [9-8], Louisville City thắng | ||||||
| 21/04/2022 01:30 |
(FT) | Atlanta United[MLS-4] Chattanooga |
6 0 |
3 0 |
MF | ME | |
| 21/04/2022 03:00 |
(FT) | San Antonio[USL CH-4] Austin Aztex[MLS-1] |
1 1 |
0 0 |
MF | ME | |
| 90 phút [1-1], 120 phút [2-1], San Antonio thắng | ||||||
| 21/04/2022 03:30 |
(FT) | Real Salt Lake[MLS-6] Northern Colorado |
0 1 |
0 0 |
MF | ME | |
| 21/04/2022 04:30 |
(FT) | Phoenix Rising Arizona U[USL CH-7] New Mexico United[USL CH-14] |
2 1 |
1 0 |
MF | ME | |
| 21/04/2022 04:30 |
(FT) | Sacramento Republic Fc[USL CH-10] Central Valley Fuego |
2 1 |
1 0 |
MF | ME | |
| 21/04/2022 04:30 |
(FT) | Los Angeles FC[MLS-2] Orange County Fc[USL CH-21] |
5 1 |
3 0 |
MF | ME | |