| Time | Status | Match | FT | H1 | Stats |
| 03/12/2021 21:00 |
(FT) | Granada[16] Alaves[15] |
2 1 |
1 0 |
MF | ME |
| 04/12/2021 14:00 |
(FT) | Sevilla[4] Villarreal[12] |
1 0 |
1 0 |
MF | ME |
| 04/12/2021 16:15 |
(FT) | Barcelona[7] Real Betis[5] |
0 1 |
0 0 |
MF | ME |
| 04/12/2021 18:30 |
(FT) | Atletico Madrid[2] Mallorca[14] |
1 2 |
0 0 |
MF | ME |
| 04/12/2021 21:00 |
(FT) | Real Sociedad[3] Real Madrid[1] |
0 2 |
0 0 |
MF | ME |
| 05/12/2021 14:00 |
(FT) | Rayo Vallecano[6] Espanyol[9] |
1 0 |
0 0 |
MF | ME |
| 05/12/2021 16:15 |
(FT) | Elche[17] Cadiz[18] |
3 1 |
1 0 |
MF | ME |
| 05/12/2021 18:30 |
(FT) | Levante[20] Osasuna[10] |
0 0 |
0 0 |
MF | ME |
| 05/12/2021 21:00 |
(FT) | Celta Vigo[13] Valencia[11] |
1 2 |
1 1 |
MF | ME |
| 06/12/2021 21:00 |
(FT) | Getafe[19] Athletic Bilbao[8] |
0 0 |
0 0 |
MF | ME |