| Time | Status | Match | FT | H1 | Stats |
| 25/09/2021 17:00 |
(FT) | Gudja United[8] Valletta FC[6] |
2 0 |
1 0 |
MF | ME |
| 25/09/2021 19:00 |
(FT) | Floriana[4] Hamrun Spartans[10] |
1 2 |
0 2 |
MF | ME |
| 25/09/2021 21:00 |
(FT) | Hibernians FC[1] Santa Lucia[9] |
1 1 |
1 1 |
MF | ME |
| 26/09/2021 17:00 |
(FT) | Gzira United[9] Birkirkara FC[2] |
1 1 |
1 1 |
MF | ME |
| 26/09/2021 19:00 |
(FT) | Sirens[3] Sliema Wanderers FC[11] |
2 2 |
0 0 |
MF | ME |
| 26/09/2021 21:00 |
(FT) | Mosta[12] Balzan[5] |
2 1 |
1 1 |
MF | ME |